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KMID : 1123920100240020266
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 2 p.266 ~ p.271
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( Effects of Chestnut Inner Shell Extract on 3T3-L1 Preadipocyte Differentiation )
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Lee Seon-Goo
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Abstract
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Obesity occurred by energy imbalance, is increasing regardless of race, sex, age, and related to the metabolic syndrome, diabetes and cardiovascular disease. Since adipose tissue plays a critical role in regulating energy homeostasis, understanding of adipogenesis pathway and finding of regulatory mechanism for adipogenesis can be helpful to manage obesity as well as obesity-related diseases. In this study, to investigate the effects of Chestnut Inner Shell(CIS) extract on the adipogenesis in 3T3-L1 preadipocytes, 3T3-L1 preadipocytes were differentiated with adipogenic reagents for 9 days in the absence or presence of CIS extract ranging from 10 - 100 . The effect of CIS extract on 3T3-L1 differentiation was examined by measuring intracelluar lipid droplet and triglyceride contents. CIS extract remarkably inhibited lipid accumulation(about 45% inhibition at 100 of CIS extract) and slightly decreased triglyceride contents(about 15% decrease at 100 of CIS extract) in 3T3-L1 preadipocytes at the concentration showing no cytotoxicity.
These results demonstrated that CIS extract significantly inhibit adipogenesis and can be used for the regulation of obesity.
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KEYWORD
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Chestnut Inner Shell(CIS), obesity, 3T3-L1 preadipocyte, Oil Red-O, lipid accumulation, triglyceride
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